iMOS® (mannan oligosaccharides)

● Mannan oligosaccharides obtained by enzymatic hydrolysis of konjac glucomannans.

 

● Approved by CFDA (China Food and Drug Administration) as a new and safe food ingredient.

 

● Improves gut function and microbiota, relieves allergies, and reduces infection.


Details

Benefits

Applications

Improves gut microbiota & function

  • iMOS® improves gut microbiota and function, and helps to relieve the symptoms associated with intestinal inflammations (constipation & diarrhea)

Intestinal inflammations (IBS, IBD, etc.) are often associated with the destruction of intestinal structural integrity. iMOS™ can improve gut integrity by increasing the length of the small intestinal villus, thickening the wall of the small intestine.

  • iMOS® improves diabetes (type II) control

Type II diabetes is associated with obesity, and patients are more likely to develop IR. IR is a condition in which cells no longer respond to the hormone and no longer absorb glucose. Experiments show that iMOS® is effective in reducing plasma glucose (FBG), hemoglobin A1C (HbA1c), and HOMA-IR, and a synergistic effect is observed when combining iMOS® and MF (the most widely used first-line drug for the treatment of type II diabetes). It also increases the abundance of Akkermansia muciniphila and Bifidobacterium pseudolongum, which is positively associated with the prevention and treatment of obesity and diabetes (type II) (Fig.1). 

dfa

Fig.1 iMOS® effectively improves the indicators of type II diabetes and also regulates the flora structure of the intestines. 

Ref: Prebiotic mannan-oligosaccharides augment the hypoglycemic effects of MF in correlation with modulating gut microbiota. Zheng et al. J. Agric. Food Chem. 2018 Apr. 27


Relieves allergies

  • iMOS® supports the prevention and treatment of autoimmune diseases, including allergies

There are many forms of allergies, the most common of which are IgE mediated. Allergies develop when the immune system mounts a T helper 2 (TH2) cell-mediated response against allergic epitopes. Common IgE-mediated allergies include those to food (peanuts, cow’s milk, egg, soy, wheat, shellfish and fish) and pollen (Fig.2).

图片11

Fig.2 The most common allergens are divided into three types according to different sensitization pathways: inhalation,ingestion and contact.

iMOS® induces regulatory T cells (Treg) and increases the ratio of Treg cells to TH2 cells (Treg/TH2), which leads to the shift from the IgE to IgG4 isotype. IgG4 antibodies compete with IgE antibodies for food allergens, leading to a desensitization to oral antigens in the gut (Fig.3) 

图片2

Fig.3 The process of IgE-mediated allergy and desensitization to oral antigens in the gut.

Ref: Food allergy: immune mechanisms, diagnosis and immunotherapy. Yu et al. Nature Reviews Immunology 16, 751–765(2016).


Reduces infection

  • iMOS® competes against pathogenic bacteria for host cell binding sites

There are many mannose-modified glycoproteins on the surface of human cells. Recent studies have found that pathogenic bacteria, such as Escherichia coli (E.coli), can bind to human cells through the binding of FimH protein at the end of pilus to mannose of glycoprotein. iMOS® competes for the binding of FimH of E.coli, which abolishes their colonization. Thus, it acts as an antibiotic replacement for the treatment of infections (Fig.4)

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Fig.4 iMOS® competes against pathogenic bacteria for host cell binding sites

Ref: Selective depletion of uropathogenic E. coli from the gut by a FimH antagonist. Spaulding CN et al. 2017.Nature 546:528-532.


Prolongs life span

  • iMOS® supplementation can extend life span by promoting gut proliferative homeostasis

The model organism used in the experiment is Drosophila melanogaster. It is ideal for aging studies due to its relatively short life span and ease of environmental and genetic manipulations. iMOS® mannan oligosaccharides (MOS) supplementation increases the abundance of benign microbes like Acetobacter and thus limits the gut dysbiosis. Usually, the dysregulation of interactions between intestinal epithelium and commensal bacteria leads to excessively elevated proliferation of intestinal stem cells (ISCs). The iMOS® treatment reduces ISCs proliferation rate and gut shorting by suppressing the stress- and growth-signaling pathways (JAK/STAT and EGFR/MAPK pathways). iMOS® treatment also enhances the immune system by inducing the expression of antimicrobial peptides. As a consequence, the mean life span is prolonged in both sexes across different genetic backgrounds, regardless of mating status (mated males: increased by 20.2%, mated females: increased by 14.88% and by 27.48% in virgin females) (Fig.5).lifespan999

Fig.5 iMOS® supplementation  extends life span and promotes gut proliferative homeostasis

Ref: Glucomannan hydrolysate promotes gut proliferative homeostasis and extends life span in drosophila melanogaster. Si et al. J Gerontol A Biol Sci Med Sci, 2018.

 

 

 


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  • Improves gut microbiota & function

    • iMOS® improves gut microbiota and function, and helps to relieve the symptoms associated with intestinal inflammations (constipation & diarrhea)

    Intestinal inflammations (IBS, IBD, etc.) are often associated with the destruction of intestinal structural integrity. iMOS™ can improve gut integrity by increasing the length of the small intestinal villus, thickening the wall of the small intestine.

    • iMOS® improves diabetes (type II) control

    Type II diabetes is associated with obesity, and patients are more likely to develop IR. IR is a condition in which cells no longer respond to the hormone and no longer absorb glucose. Experiments show that iMOS® is effective in reducing plasma glucose (FBG), hemoglobin A1C (HbA1c), and HOMA-IR, and a synergistic effect is observed when combining iMOS® and MF (the most widely used first-line drug for the treatment of type II diabetes). It also increases the abundance of Akkermansia muciniphila and Bifidobacterium pseudolongum, which is positively associated with the prevention and treatment of obesity and diabetes (type II) (Fig.1). 

    dfa

    Fig.1 iMOS® effectively improves the indicators of type II diabetes and also regulates the flora structure of the intestines. 

    Ref: Prebiotic mannan-oligosaccharides augment the hypoglycemic effects of MF in correlation with modulating gut microbiota. Zheng et al. J. Agric. Food Chem. 2018 Apr. 27


    Relieves allergies

    • iMOS® supports the prevention and treatment of autoimmune diseases, including allergies

    There are many forms of allergies, the most common of which are IgE mediated. Allergies develop when the immune system mounts a T helper 2 (TH2) cell-mediated response against allergic epitopes. Common IgE-mediated allergies include those to food (peanuts, cow’s milk, egg, soy, wheat, shellfish and fish) and pollen (Fig.2).

    图片11

    Fig.2 The most common allergens are divided into three types according to different sensitization pathways: inhalation,ingestion and contact.

    iMOS® induces regulatory T cells (Treg) and increases the ratio of Treg cells to TH2 cells (Treg/TH2), which leads to the shift from the IgE to IgG4 isotype. IgG4 antibodies compete with IgE antibodies for food allergens, leading to a desensitization to oral antigens in the gut (Fig.3) 

    图片2

    Fig.3 The process of IgE-mediated allergy and desensitization to oral antigens in the gut.

    Ref: Food allergy: immune mechanisms, diagnosis and immunotherapy. Yu et al. Nature Reviews Immunology 16, 751–765(2016).


    Reduces infection

    • iMOS® competes against pathogenic bacteria for host cell binding sites

    There are many mannose-modified glycoproteins on the surface of human cells. Recent studies have found that pathogenic bacteria, such as Escherichia coli (E.coli), can bind to human cells through the binding of FimH protein at the end of pilus to mannose of glycoprotein. iMOS® competes for the binding of FimH of E.coli, which abolishes their colonization. Thus, it acts as an antibiotic replacement for the treatment of infections (Fig.4)

    bcaa77a12

    Fig.4 iMOS® competes against pathogenic bacteria for host cell binding sites

    Ref: Selective depletion of uropathogenic E. coli from the gut by a FimH antagonist. Spaulding CN et al. 2017.Nature 546:528-532.


    Prolongs life span

    • iMOS® supplementation can extend life span by promoting gut proliferative homeostasis

    The model organism used in the experiment is Drosophila melanogaster. It is ideal for aging studies due to its relatively short life span and ease of environmental and genetic manipulations. iMOS® mannan oligosaccharides (MOS) supplementation increases the abundance of benign microbes like Acetobacter and thus limits the gut dysbiosis. Usually, the dysregulation of interactions between intestinal epithelium and commensal bacteria leads to excessively elevated proliferation of intestinal stem cells (ISCs). The iMOS® treatment reduces ISCs proliferation rate and gut shorting by suppressing the stress- and growth-signaling pathways (JAK/STAT and EGFR/MAPK pathways). iMOS® treatment also enhances the immune system by inducing the expression of antimicrobial peptides. As a consequence, the mean life span is prolonged in both sexes across different genetic backgrounds, regardless of mating status (mated males: increased by 20.2%, mated females: increased by 14.88% and by 27.48% in virgin females) (Fig.5).lifespan999

    Fig.5 iMOS® supplementation  extends life span and promotes gut proliferative homeostasis

    Ref: Glucomannan hydrolysate promotes gut proliferative homeostasis and extends life span in drosophila melanogaster. Si et al. J Gerontol A Biol Sci Med Sci, 2018.

     

     

     

    iMOS is a premium quality prebiotic with a slightly sweet taste. It is water soluble, stable, and can be used in many forms in food and dietary products. It is ideal for yogurt, milk powder, beverages, etc. iMOS comes in the form of a powder, and can also be customized into different sizes according to customer requirements.

     

    ● Dietary supplement

    in forms of tablets, capsules, powders…

    ● Meal replacement products

    meal replacement powders, milkshakes…

    ● Functional drinks

    sports drinks, vitamin drinks, juices…

    ● Dairy products

    liquid milk (formula milk, yogurt), milk powder, condensed milk, ice cream…

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