iMOS® supplementation can extend life span by promoting gut proliferative homeostasis
The model organism used in the experiment is Drosophila melanogaster. It is ideal for aging studies due to its relatively short life span and ease of environmental and genetic manipulations. iMOS® mannan oligosaccharides (MOS) supplementation increases the abundance of benign microbes like Acetobacter and thus limits the gut dysbiosis. Usually, the dysregulation of interactions between intestinal epithelium and commensal bacteria leads to excessively elevated proliferation of intestinal stem cells (ISCs). The iMOS® treatment reduces ISCs proliferation rate and gut shorting by suppressing the stress- and growth-signaling pathways (JAK/STAT and EGFR/MAPK pathways). iMOS® treatment also enhances the immune system by inducing the expression of antimicrobial peptides. As a consequence, the mean life span is prolonged in both sexes across different genetic backgrounds, regardless of mating status (mated males: increased by 20.2%, mated females: increased by 14.88% and by 27.48% in virgin females) (Fig.5).
Fig.5 iMOS® supplementation extends life span and promotes gut proliferative homeostasis.
Ref: Glucomannan hydrolysate promotes gut proliferative homeostasis and extends life span in drosophila melanogaster. Si et al. J Gerontol A Biol Sci Med Sci, 2018.