iMOS® supports the prevention and treatment of autoimmune diseases, including allergies
There are many forms of allergies, the most common of which are IgE mediated. Allergies develop when the immune system mounts a T helper 2 (TH2) cell-mediated response against allergic epitopes. Common IgE-mediated allergies include those to food (peanuts, cow’s milk, egg, soy, wheat, shellfish and fish) and pollen (Fig.2).
Fig.2 The most common allergens are divided into three types according to different sensitization pathways: inhalation, ingestion and contact.
iMOS® induces regulatory T cells (Treg) and increases the ratio of Treg cells to TH2 cells (Treg/TH2), which leads to the shift from the IgE to IgG4 isotype. IgG4 antibodies compete with IgE antibodies for food allergens, leading to a desensitization to oral antigens in the gut (Fig.3)
Fig.3 The process of IgE-mediated allergy and desensitization to oral antigens in the gut.
Ref: Food allergy: immune mechanisms, diagnosis and immunotherapy. Yu et al. Nature Reviews Immunology 16, 751–765(2016).